What is most important is that you avoid the regular consumption or overconsumption of furanocoumarin in any form. Policy. Grapefruit contains a chemical that interferes with your body’s ability to break down or metabolize certain statin medications. Why Grapefruit and Statin Drugs Do Not Mix, Ⓒ 2020 About, Inc. (Dotdash) — All rights reserved. Hung WL, Suh JH, Wang Y. Chemistry and health effects of furanocoumarins in grapefruit. Cleveland Clinic © 1995-2020. PCSK9 Inhibitors for Cholesterol—Are They Really Miracle Drugs? CORONAVIRUS: UPDATED VISITOR RESTRICTIONS, INCREASED SAFETY MEASURES + COVID-19 TESTING. This is because the two drugs are broken down by an entirely different enzyme known as CYP2C9. The introduction of statin medications has helped patients: It’s true that changing your diet and lifestyle can help bring down LDL levels, but sticking to a strict diet and exercise regimen isn’t easy. Switch to oranges or other safe fruits and save grapefruit for special occasions. Atorvastatin interacts with grapefruit juice if you drink large quantities (more than 1.2 litres daily), but an occasional glass is thought to be safe. Advertising on our site helps support our mission. Severe side effects include muscle fiber breakdown and kidney failure. There is no absolute consensus about how much grapefruit a person can safely eat while taking statins, but Dr. Hazen takes a measured approach with his patients. Problems can occur for those who are sensitive to statin medications or those who have kidney disease or other illnesses. Grapefruit juice and some drugs don't mix. Eating grapefruit while taking these drugs can increase the risk of side effects. As with any medication, taking the correct dose of statins is important. “Patients often ask about grapefruit and statins — and whether they can eat the fruit or drink the juice when on statins,” he says. Grapefruit juice decreases the activity of the cytochrome P450 3A4 (CYP3A4) enzymes that are responsible for breaking down many drugs and toxins. Eating grapefruit while taking these drugs can increase the risk of side effects. Statin medications work steadily and reliably to help regulate LDL levels — even if you come up short on exercise or indulge in a slice of cheesecake once too often. Taking a Statin After a Heart Attack? You have successfully subscribed to our newsletter. When this happens, the drug concentration can increase dramatically and, with it, the risk of side effects. If you consume grapefruit every now or then, it is unlikely to do any real harm. When statin takers eat large amounts of grapefruit, the level of statins in their blood can increase, raising the possibility of side effects. Luckily for grapefruit fans, there are cases in which moderate amount should be safe. In others, it can interfere with protein transporters in the blood, reducing the concentration and effect of the drug. Can You Have Grapefruit Juice If You Take Plavix? No one has the same reaction when mixing grapefruit with lovastatin, atorvastatin, or simvastatin. Furanocoumarins are also found in other fruit (eg, pomegranates), and in vegetables (eg, parsnips and celery), however, they are especially concentrated in grapefruit juice and fresh grapefruits. Limit your consumption of grapefruit or switch to "safe" citrus fruits, such as blood oranges, clementines, lemons, limes, mandarins, navel oranges, and tangerines. While women and people over 65 appear to be at greatest risk, studies remain conflicted as to the actual risk. Jennifer Moll, MS, PharmD, is a pharmacist actively involved in educating patients about the importance of heart disease prevention. The interaction is caused by an organic compound in grapefruit known as furanocoumarin. Furanocoumarins are found in other fruits and vegetables (such as celery, parsnips, and pomegranates), but are especially high in grapefruit and grapefruit juice. Bitter oranges, pomelos, tangelos, and Seville oranges contain high levels of furanocoumarin and should also be avoided. Grapefruit juice and some drugs don't mix. Advertising on our site helps support … Read More, Fitness, health and wellness tips sent to you weekly. Read our, Medically reviewed by Richard N. Fogoros, MD, Medically reviewed by Jeffrey S. Lander, MD, Medically reviewed by Yasmine S. Ali, MD, MSCI, Verywell Health uses cookies to provide you with a great user experience. Side effects from grapefruit-statin interaction can be mild, such as muscle and joint pain. Cardiologist Steven Nissen, MD, points out that only certain statin medications interact negatively with grapefruit. This warning has led to a lot of questions from people taking this type of medication.
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